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is an extremely rare genetic disease that was first identified in 1948 by W.L. Donohue. There have only been 49 cases reported worldwide since is first reporting in 1948 until 1987. This disease is also known as Donohue Syndrome, in his honor. Most patients di ....

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.... related (e.g. first cousins). Clinical traits are as follows:  Hyperpigmented skin or as otherwise known, Acanthosis nigricans. This symptom is not exclusive to , as it is caused by high insulin levels. This pigmentation normally occurs in areas of the body where flexing and bending occurs, such as the back of the neck.  Reddening of the skin or erythema. This is caused by localized irritation. Most often the areas of the body most affected are those such as the gluteal cleft, groin area, and other places that friction might occur. It is not limited to these areas as it occurs on any other part of the body as well, such as th ....