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Keratinization, absence of granular layer, and depositation of antibodies and complement components in the stratum corneum. Most notable is the hyperproliferation of keratinocytes in the epidermis. These keratinocytes exhibit an increased mitotic rate and have ten ....

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.... for males. Type II affects people over sixty years of age. There are several immunological abnormalities associated with psoriasis. Early psoriatic changes occur in advancing lesions before the accumulation of inflammatory cells. These changes are mediated by activated CD4+ T lymphocytes and can be detected before visible pathology to the skin occurs. Activated T lymphocytes exhibiting an increase in HLA-DR and IL-2R can be seen in close proximity to Langerhans cells in the dermis before lesion formation. Since Langerhans cells are antigen presenting cells, activation of the T cells may occur by the recognition of an as-yet unidentifie ....