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"As a physician, there is nothing as gratifying as administering Tensilon to an undiagnosed myasthenic patient… except maybe giving benadryl to a patient who OD'd on compazine." -Kenneth R. Einberg MD, 1999 Introduction (MG) is one of the most common neuromuscu ....

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.... but first-degree relatives have a 1000x greater risk of developing MG than the general population, suggesting a genetic predisposition. Clinical Features The cardinal feature of MG is muscle weakness and fatiguability. The muscles most commonly affected are the oculomotors, which cause ptosis or diplopia. MG can also commonly present with oropharyngeal muscle weakness. The patient may regurgitate food through the nose, be unable to chew meat, speak in a markedly ‘nasal’ tone, or have a history of choking on food/secretions. MG can also present with limb weakness and rarely respiratory distress. The weakness typically (but not always) worsen ....