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An analytic review of Immunotherapy for Cocaine Addiction by Donald W. Landry (1997) and Buprenorphine Suppresses Cocaine Self-Administration by Rhesus Monkeys by Nancy Mello et al. (1989) The general unsuccessfulness of treating cocaine addicts has led to the d ....

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.... no positive reinforcement, and would gradually be able to become successful in a treatment program. The problem with this point of view is that cocaine has not been shown to be very physically addicting, as there are no major symptoms of withdrawal that the patient is trying to combat by self-administering more of the drug. By making the drug ineffective in the blood stream, addicts would not receive what is thought to be positive reinforcement through cocaine's effects on the dopaminergic systems in the brain, but there is no evidence to prove that it would therefore stop them from taking it in increasingly higher doses, until the amount of dr ....