Beginning of Essay
Of all gynecologic malignancies, continues to have the highest mortality and is the most difficult to diagnose. In the United States female population, ranks fifth in absolute mortality among cancer related deaths (13,000/yr). In most reported cases, , when fi ....

Middle of Essay
.... cavity. Tumor development has been associated with aberrant, dysfunctional expression and/or mutation of various genes. This can include oncogene overexpression, amplification or mutation, aberrant tumor suppressor expression or mutation. Also, subversion of host antitumor immune responses may play a role in the pathogenesis of cancer (Sharp, 77). Ovarian clear cell adenocarcinoma was first described by Peham in 1899 as "hypernephroma of the ovary" because of its resemblance to renal cell carcinoma. By 1939, Schiller noted a histologic similarity to mesonephric tubules and classified these tumors as "mesonephromas." In 1944, Saphi ....